CryptomicsDB pview

gene_id CNAG_00034

gene_name Rpl9b

log2-fold-change 2.58

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0002181~cytoplasmic translation

cellular-component

GO:0022625~cytosolic large ribosomal subunit

metabolic-function

GO:0003735~structural constituent of ribosome,GO:0019843~rRNA binding

metabolic-pathways

cng03010:Ribosome

gene_id CNAG_00057

gene_name Fbp1

log2-fold-change 3.23

p-value 4.64e-05

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0005986~sucrose biosynthetic process,GO:0006000~fructose metabolic process,GO:0006002~fructose 6-phosphate metabolic process,GO:0006094~gluconeogenesis,GO:0030388~fructose 1,6-bisphosphate metabolic process

cellular-component

GO:0005829~cytosol

metabolic-function

GO:0042132~fructose 1,6-bisphosphate 1-phosphatase activity,GO:0046872~metal ion binding

metabolic-pathways

cng00010:Glycolysis / Gluconeogenesis,cng00030:Pentose phosphate pathway,cng00051:Fructose and mannose metabolism,cng00680:Methane metabolism,cng01100:Metabolic pathways,cng01110:Biosynthesis of secondary metabolites,cng01200:Carbon metabolism

gene_id CNAG_00091

gene_name Hypothetical Protein

log2-fold-change 2.94

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study in vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

gene_id CNAG_00100

gene_name Stress-Induced-Phosphoprotein 1

log2-fold-change -2.44

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

metabolic-function

GO:0051879~Hsp90 protein binding

gene_id CNAG_00104

gene_name Elongation Factor 3

log2-fold-change 2.89

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0006338~chromatin remodeling

cellular-component

GO:0005737~cytoplasm

metabolic-function

GO:0003723~RNA binding,GO:0003746~translation elongation factor activity,GO:0005524~ATP binding,GO:0016887~ATP hydrolysis activity

gene_id CNAG_00131

gene_name Alcohol Dehydrogenase

log2-fold-change 3.29

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

cellular-component

GO:0005739~mitochondrion

metabolic-function

GO:0008270~zinc ion binding,GO:0016491~oxidoreductase activity

gene_id CNAG_00142

gene_name Hypothetical Protein

log2-fold-change 2.61

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0006364~rRNA processing

cellular-component

GO:0005730~nucleolus

metabolic-function

GO:0003723~RNA binding

gene_id CNAG_00149

gene_name Nadh Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4

log2-fold-change 2.53

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

cellular-component

GO:0005751~mitochondrial respiratory chain complex IV

metabolic-pathways

cng00190:Oxidative phosphorylation,cng01100:Metabolic pathways

gene_id CNAG_00162

gene_name Aox1

log2-fold-change -2.5

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0010230~alternative respiration

cellular-component

GO:0005739~mitochondrion,GO:0005743~mitochondrial inner membrane,GO:0070469~respirasome

metabolic-function

GO:0009916~alternative oxidase activity,GO:0046872~metal ion binding

gene_id CNAG_00172

gene_name Kinesin

log2-fold-change -2.73

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0000070~mitotic sister chromatid segregation,GO:0007018~microtubule-based movement,GO:0007019~microtubule depolymerization

cellular-component

GO:0005634~nucleus,GO:0005871~kinesin complex,GO:0061673~mitotic spindle astral microtubule,GO:1990023~mitotic spindle midzone

metabolic-function

GO:0005524~ATP binding,GO:0008017~microtubule binding,GO:0008574~plus-end-directed microtubule motor activity,GO:0016887~ATP hydrolysis activity

gene_id CNAG_00191

gene_name Etoposide-Induced Protein

log2-fold-change 3.0

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0016236~macroautophagy

cellular-component

GO:0005783~endoplasmic reticulum,GO:0016020~membrane

gene_id CNAG_00235

gene_name Amt1 (Mep1)

log2-fold-change -3.61

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

cellular-component

GO:0005886~plasma membrane

metabolic-function

GO:0008519~ammonium channel activity

gene_id CNAG_00235

gene_name Amt1 (Mep1)

log2-fold-change 2.27

p-value 0.01

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

cellular-component

GO:0005886~plasma membrane

metabolic-function

GO:0008519~ammonium channel activity

gene_id CNAG_00237

gene_name 3-Isopropylmalate Dehydratase, Large Subunit

log2-fold-change -2.49

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0008652~amino acid biosynthetic process,GO:0009098~L-leucine biosynthetic process

cellular-component

GO:0009316~3-isopropylmalate dehydratase complex

metabolic-function

GO:0003861~3-isopropylmalate dehydratase activity,GO:0046872~metal ion binding,GO:0051539~4 iron,4 sulfur cluster binding

metabolic-pathways

cng00290:Valine,leucine and isoleucine biosynthesis,cng01100:Metabolic pathways,cng01110:Biosynthesis of secondary metabolites,cng01210:2-Oxocarboxylic acid metabolism,cng01230:Biosynthesis of amino acids

gene_id CNAG_00247

gene_name Lys9

log2-fold-change -3.39

p-value 2.58e-05

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0019878~lysine biosynthetic process via aminoadipic acid,GO:0033512~L-lysine catabolic process to acetyl-CoA via saccharopine

cellular-component

GO:0005737~cytoplasm

metabolic-function

GO:0004753~saccharopine dehydrogenase activity,GO:0047130~saccharopine dehydrogenase (NADP+,L-lysine-forming) activity,GO:0047131~saccharopine dehydrogenase (NAD+,L-glutamate-forming) activity

metabolic-pathways

cng00310:Lysine degradation,cng01100:Metabolic pathways,cng01110:Biosynthesis of secondary metabolites

gene_id CNAG_00259

gene_name Bud Site Selection Protein

log2-fold-change -3.04

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0070476~rRNA (guanine-N7)-methylation

cellular-component

GO:0005730~nucleolus,GO:0005737~cytoplasm

metabolic-function

GO:0016435~rRNA (guanine) methyltransferase activity

gene_id CNAG_00305

gene_name Chaperone Activator

log2-fold-change -2.62

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0006457~protein folding

cellular-component

GO:0005829~cytosol,GO:0016020~membrane

metabolic-function

GO:0001671~ATPase activator activity,GO:0051087~protein-folding chaperone binding

gene_id CNAG_00315

gene_name Hhe Domain-Containing Protein

log2-fold-change -1.89

p-value 0.01

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0098771~inorganic ion homeostasis

gene_id CNAG_00371

gene_name Methylglutaconyl-Coa Hydratase

log2-fold-change 3.66

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0006635~fatty acid beta-oxidation

cellular-component

GO:0005739~mitochondrion

metabolic-function

GO:0004300~enoyl-CoA hydratase activity

metabolic-pathways

cng00280:Valine,leucine and isoleucine degradation,cng01100:Metabolic pathways

gene_id CNAG_00371

gene_name Methylglutaconyl-Coa Hydratase

log2-fold-change -2.08

p-value 0.01

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0006635~fatty acid beta-oxidation

cellular-component

GO:0005739~mitochondrion

metabolic-function

GO:0004300~enoyl-CoA hydratase activity

metabolic-pathways

cng00280:Valine,leucine and isoleucine degradation,cng01100:Metabolic pathways

gene_id CNAG_00373

gene_name Glucan 1,3-Beta-Glucosidase

log2-fold-change 2.93

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study in vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0009251~glucan catabolic process

cellular-component

GO:0005576~extracellular region,GO:0009986~cell surface,GO:0016020~membrane

metabolic-function

GO:0004338~glucan exo-1,3-beta-glucosidase activity

metabolic-pathways

cng00500:Starch and sucrose metabolism,cng01100:Metabolic pathways

gene_id CNAG_00393

gene_name 1,4-Alpha-Glucan-Branching Enzyme

log2-fold-change 3.07

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0005978~glycogen biosynthetic process,GO:0005982~starch metabolic process

cellular-component

GO:0005829~cytosol

metabolic-function

GO:0003844~1,4-alpha-glucan branching enzyme activity,GO:0004553~hydrolase activity,hydrolyzing O-glycosyl compounds,GO:0043169~cation binding,GO:0102752~1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)

metabolic-pathways

cng00500:Starch and sucrose metabolism,cng01100:Metabolic pathways,cng01110:Biosynthesis of secondary metabolites

gene_id CNAG_00393

gene_name 1,4-Alpha-Glucan-Branching Enzyme

log2-fold-change 3.81

p-value 7.83e-05

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study in vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0005978~glycogen biosynthetic process,GO:0005982~starch metabolic process

cellular-component

GO:0005829~cytosol

metabolic-function

metabolic-pathways

cng00500:Starch and sucrose metabolism,cng01100:Metabolic pathways,cng01110:Biosynthesis of secondary metabolites

gene_id CNAG_00441

gene_name Imd1

log2-fold-change 2.67

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0006177~GMP biosynthetic process,GO:0006183~GTP biosynthetic process

cellular-component

GO:0005737~cytoplasm

metabolic-function

GO:0000166~nucleotide binding,GO:0003938~IMP dehydrogenase activity,GO:0046872~metal ion binding

metabolic-pathways

cng00230:Purine metabolism,cng01100:Metabolic pathways,cng01110:Biosynthesis of secondary metabolites,cng01232:Nucleotide metabolism

gene_id CNAG_00442

gene_name Cyclin

log2-fold-change 2.84

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

cellular-component

GO:0000307~cyclin-dependent protein kinase holoenzyme complex,GO:0005634~nucleus

metabolic-function

GO:0016538~cyclin-dependent protein serine/threonine kinase regulator activity,GO:0019901~protein kinase binding

gene_id CNAG_00456

gene_name Hypothetical Protein

log2-fold-change 3.08

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

gene_id CNAG_00456

gene_name Hypothetical Protein

log2-fold-change 3.31

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study in vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

gene_id CNAG_00460

gene_name Liv1

log2-fold-change -3.65

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

biological-process

GO:0045944~positive regulation of transcription by RNA polymerase II

cellular-component

GO:0090575~RNA polymerase II transcription regulator complex

metabolic-function

GO:0003700~DNA-binding transcription factor activity,GO:0046983~protein dimerization activity

gene_id CNAG_00462

gene_name Electron-Transferring-Flavoprotein Dehydrogenase

log2-fold-change -3.13

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study In vivo vs Ex vivo

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

cellular-component

GO:0005739~mitochondrion

metabolic-function

GO:0004174~electron-transferring-flavoprotein dehydrogenase activity,GO:0046872~metal ion binding,GO:0051539~4 iron,4 sulfur cluster binding

gene_id CNAG_00484

gene_name 2-Oxoisovalerate Dehydrogenase E2 Component (Dihydrolipoyl Transacylase)

log2-fold-change 3.27

p-value 0.0

expression UP

organism Homo sapiens

specie-cryptococcus Cryptococcus neoformans

comparation-in-study Ex vivo CSF vs YPD

approach Transcriptomic

technique RNA-seq

reference https://doi.org/10.1128/mbio.01087-13

cellular-component

GO:0005739~mitochondrion

metabolic-function

GO:0016407~acetyltransferase activity,GO:0031405~lipoic acid binding

metabolic-pathways

cng00280:Valine,leucine and isoleucine degradation,cng00640:Propanoate metabolism,cng00785:Lipoic acid metabolism,cng01100:Metabolic pathways,cng01110:Biosynthesis of secondary metabolites,cng01210:2-Oxocarboxylic acid metabolism