Forensic DNA phenotyping aims to predict appearance traits of an individual based on a DNA sample. Eyes and Skin colors are highly heritable genetic traits and are the most obvious and distinguishable externally visible characteristics to be used for human identification. Genotype-phenotype association studies have focused in detecting single nucleotide polymorphisms (SNPs) within genes directly or indirectly involved in pigments synthesis. Here, we introduce you to an easy system for eyes and skin phenotype prediction through DNA.
BR-EASE - Brazilian Eye and Skin Estimator
Overview
Instructions
- Select the corresponding genotypes in the selection box and click below to predict the phenotypes.
- Eyes phenotypes are divided into three classes: Blue, Intermediate and Brown.
- Skin phenotypes are divided into three classes: Light, Intermediate and Dark
- Information about genes and SNPs are available on the corresponding links.
If you have any questions, please contact us: mdorn@inf.ufrgs.br
BR-EASE: Eye Color Estimator
Ten SNPs were selected in the following human pigmentation associated genes: ASIP (rs6119471), DDB1 (rs11230664), HERC2 (rs6497271, rs1129038, rs12913832), MFSD12 (rs10424065, rs6510760), OCA2 (rs1800407), SLC24A5 (rs1426654) and SLC24A4 (rs2402130).
SNP Panel for Eye Color Prediction
| SNP | Genotype | Gene |
|---|---|---|
| rs6119471 | ASIP | |
| rs11230664 | DDB1 | |
| rs1129038 | HERC2 | |
| rs12913832 | HERC2 | |
| rs6497271 | HERC2 | |
| rs10424065 | MFSD12 | |
| rs6510760 | MFSD12 | |
| rs1800407 | OCA2 | |
| rs1426654 | SLC24A5 | |
| rs2402130 | SLC24A4 |
BR-EASE: Skyn Color Estimator
Twenty Five SNPs were selected in the following human pigmentation associated genes: ASIP (rs2424984, rs6119471), DDB1 (rs11230664), HERC2 (rs1129038, rs11636232, rs16950987, rs2238289, rs4932620, rs6497271), MC1R (rs1805006, rs1805009, rs3212345, rs885479), MFSD12 (rs10424065, rs6510760), NPLOC4 (rs9894429), OCA2 (rs1037208, rs1375164, rs3794606, rs4778232), SLC24A5 (rs1426654), SLC45A2 (rs16891982, rs183671), TMEM138 (rs7948623) and TYR (rs1042602).
SNP Panel for Skin Color Prediction
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